Post animé characters who are orphans

Naruto (Naruto Shippuden)

Death Note;all of the people from Wammy's House: L, Mello, Near, and Matt. :)

Naruto (So sad when his parents died :´( They were awesome).

Mikasa Ackerman, she was taken in par the Jaeger family

From left to right we have these three from Gundam 00.

Saji Crossroad was raised par his older sister after their father died....right up until she died too, leaving the poor guy all alone.

Louise Halevy's family was killed when Nena Trinity beamed all them to death at her cousin's wedding, leaving the poor rich girl all alone as well.

Setsuna F. Seiei/Soran Ibrahim is no exception, he killed his own family when he was in a brainwashed state.

Yukio and Rin Okumura are orphans who were adopted par the Church :)

Yuki from Uragiri wa Boku no Namae wo Shitteiru

Ciel Phamtomhive from Kuroshitsuji (or Black Butler, if toi will.)

Gray and Lucy from Fairy Tail.

Tohru Honda

Watanuki from xxxHolic.

Nowaki (Junjou Romantica)

Sasori from Naruto :(