No, I don't think so. Because, since Katherine and his realisation of his l’amour for Elena -which he won't really do anything about because of Stefan- Rose is the realist "relationship" he's had- if that makes sense. Also, Rose is EPIC!!!!!! And I think that Damon will have Bonnie conjure up a cure for her ou something, somehow.
Well, Rose got bit par a werewolf, which was meant for Damon. Before the end of the episode she starts changing, her skin is changing. When a werewolf bites someone, they die. We will see....