I completely missed the George and Izzie break-up. When she kissed Alex in the season 4 finale, I was like: oy, she is together with George.. But somehow there was no GeorgexIzzie l’amour interaction anymore...so when did they break up? :S

episode 14/15 in the 2-parter in season 4!When they a dit that its not the right time for them to be together!and the episdoe ended up with the dancing!
(p.s they are so ment to be!grrr!)

Izzie and George broke up because the timing for them to be together was off and they realized they were better as Friends and when they dated it complicated things so they just became Friends again

hhh XD

best couple on Grey's par far. i wanted them to get together from jour 1, and they DEFINITELY had chemistry...they were PERFECT for each other!! the writers screwed this up they would have been an amazing couple...and i also hate how they weren't Friends anymore after they broke up!!! this was done all wrong, stupid writers!!! ) but apparently Izzie leaves and George DIES!?!?!?!? what the hell!?!????