When the Saiyan arrive a an later, Piccolo's fondness toward Gohan results in him receiving of one of Nappa's attacks aimed to Gohan, which results in the death of Kami and the Dragon Balls. After the Saiyans are defeated, Gohan and others travel to Piccolo's homeworld Namek to revive those who died against the Saiyans with the Namekian Dragon Balls. Piccolo is resurrected on Planet Namek to help Goku and others defeat the evil Frieza. Despite his massive power increase and going head to head with Frieza's seconde tranformation, Frieza tranforms and Piccolo is defeated and severely injured par Frieza, leaving Goku to defeat him alone. Piccolo is restored to health, and waits a an until Goku arrives back on Earth. He then trains with Goku and Gohan for three years to prepare for a battle against two powerful androids created par the Red Ribbon to kill Goku.
After being defeated par Android #17 and Android #18, Piccolo seeks to unite with Kami, and gain another massive increase in power. After uniting with Kami, Piccolo becomes aware of a plus dangerous threat named Cell. Before his seconde encounter with Cell, Piccolo once again battles the androids, except this time he battles #17 one on one. After a somewhat even match, Cell arrives on the battle scene and needing to absorb the androids to complete his power, Piccolo is nearly killed par Cell, and he is forced to participate in a Martial Arts Tournament created par Cell called the Cell Games where he fights one of the seven Cell Juniors that are created par Cell, who are later destroyed par Gohan.
Seven years later, Piccolo acts as a trainer to Son Goten, Goku's seconde son, and Trunks, Vegeta's son, and their fused form Gotenks. Piccolo trains the boys in fighting the evil creature Majin Buu, but is later absorbed par Buu along with Gotenks and Gohan and incorporated into his being. He is later freed par Goku and Vegeta, and he later gives his energy to Goku's Super Spirit Bomb, which Goku uses to defeat Buu once and for all.
In Dragon Ball GT he is severely injured par Gohan while he was possessed par Baby and later dies with Earth in order to destroy the Black étoile, star Dragon Balls. He goes to Heaven but then requests he is sent to Hell in order to free Goku when he is imprisoned there. He can be seen putting Hell in order and protecting the rulers there. In the final episode, Goku stops in Hell to see Piccolo. He tells Piccolo that he will be leaving and that they are glad they met and teamed up. He also says that he has become a good friend and he will get out of Hell someday. They shake hands and Goku leaves while Piccolo stays behind.
