The Powerpuff Girls, exploring the desert, meet the Road Runner and compete with each other in a race to see who is the fastest. Unfortunately, they have someone hungry and wily right behind their tail.
The Powerpuff Girls, along with their feathery friend, are now near to the finish after their picnic break. However, the coyote returns and isn't giving up to catch his avian meal with super fast shoes. Can the four evade Wile E. for the last time? And get to the finish line?