New spoilers from Kristin 

Holy Crap!!!!!!!!!!!:0
OH GOD PLEASE DONT LET IT BE CUDDY!!!!!!! PLEASE OH PLEASE OH PLEASE!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!­!!!­!!!­!!!­!!!­!!!­!!!­!!!­!!!­!!!­!!!­!!!­!

Relax :)

From Ausiello (28.01.2009)

"Question: I heard a character might be leaving House at the end of the season. I’m scared it might be Cuddy. — Maude

Ausiello: Though exec producer Katie Jacobs played dumb when I asked her about the rumored departure at press tour, Cuddy ain’t goin’ nowhere. Trust me. That’s not to say that there aren’t big changes ahead. Hugh Laurie teased, “House undergoes some pretty traumatic stuff in the last half of the season. Not physical but mental. They have lined it up for something fairly cataclysmic, but not, cataclysmic just for the sake of being disastrous, and not just to end the season on a crazy note.” So Marcia Cross isn’t gonna blow up the hospital? Er, no. “Stuff doesn’t blow up,” he promises. “I hope we never blow things up, ever. This event is sort of contained within House’s head, [but] it is exciting.”

I panicked for a second thinking it may be Cuddy, but then I remembered Ausiello saying Cuddy wasn't leaving. Now I'm worried it'll be Wilson. It said that there will be nothing leading up to it so that rules out Thirteen cause obviously her whole Huntington's story will eventually lead to her demise.

at this point I just don't want it to be Cuddy or Wilson. ser, if it's Cuddy I'll die too. but I doubt it is... and come on! another season ending with death? there was no need for that.

Actually,
I think it might be Foreman.
Because:
-They've said that Cameron and Chase are going to be a big part of next season

-[I think] if they get rid of House, Cuddy, or Wilson, they will lose quite a few viewers... and I love them. =P

-And Thirteen is expected to die...

I don't care who it is as long as it's not Cuddy or Wilson! I will go on strike if kill either off!

Thank you so much for posting that HousefanPL!
*starts to calm down now* :]

Simple: Cuddy leaves, I leave. But i'm sure it won't be Cuddy. She adds tooooooo much to the show! I mean...that would be THE dumbest thing besides killing off HOUSE. so. As long as it's not House, Cuddy, or Wilson....I can probably deal with it.

But still...killing someone off two seasons in a row??? wow.